Klaus Pfizenmaier Selected Research

Type II Tumor Necrosis Factor Receptors

12/2021	Anti-inflammatory treatment in MPN: targeting TNFR1 and TNFR2 in JAK2-V617F-induced disease.
1/2021	The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation.
1/2020	TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice.
10/2019	Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis.
1/2019	TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes.
1/2019	Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury.
11/2018	Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis.
10/2016	Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration.
1/2016	Selective Blocking of TNF Receptor 1 Attenuates Peritoneal Dialysis Fluid Induced Inflammation of the Peritoneum in Mice.
2/2014	Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor.

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Klaus Pfizenmaier Research Topics

Disease

30	Neoplasms (Cancer) 01/2020 - 06/2002
7	Inflammation (Inflammations) 12/2021 - 01/2014
4	Multiple Sclerosis 10/2019 - 01/2014
4	Necrosis 11/2018 - 07/2009
4	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2016 - 04/2002
4	Breast Neoplasms (Breast Cancer) 02/2010 - 07/2004
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2019 - 01/2014
3	Autoimmune Diseases (Autoimmune Disease) 11/2018 - 01/2014
2	Rheumatoid Arthritis 01/2021 - 04/2008
2	Neuralgia (Stump Neuralgia) 10/2019 - 01/2019
2	Colorectal Neoplasms (Colorectal Cancer) 02/2018 - 01/2014
2	Neoplasm Metastasis (Metastasis) 02/2014 - 08/2006
2	Carcinoma (Carcinomatosis) 07/2004 - 06/2002
1	Splenomegaly 12/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2021
1	Fibrosis (Cirrhosis) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Fatty Liver 01/2020
1	Non-alcoholic Fatty Liver Disease 01/2020
1	Insulin Resistance 01/2020
1	Demyelinating Diseases (Demyelinating Disease) 10/2019
1	Ewing Sarcoma (Sarcoma, Ewing) 01/2019
1	Pain (Aches) 01/2019
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2019
1	Experimental Arthritis 01/2018
1	Animal Disease Models 10/2016
1	Pancreatic Neoplasms (Pancreatic Cancer) 02/2014
1	Hepatocellular Carcinoma (Hepatoma) 02/2013
1	Neuroinflammatory Diseases 09/2012
1	Parkinson Disease (Parkinson's Disease) 01/2011
1	Sarcoma (Soft Tissue Sarcoma) 07/2009
1	Tuberculosis (Tuberculoses) 03/2009
1	Metabolic Diseases (Metabolic Disease) 03/2009

Drug/Important Bio-Agent (IBA)

14	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2021 - 04/2002
12	LigandsIBA 01/2020 - 11/2002
12	Proteins (Proteins, Gene)FDA Link 02/2018 - 11/2002
11	Type II Tumor Necrosis Factor ReceptorsIBA 12/2021 - 04/2002
9	Type I Tumor Necrosis Factor ReceptorsIBA 12/2021 - 06/2002
7	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2021 - 04/2002
6	CytokinesIBA 12/2021 - 02/2005
6	Death Domain ReceptorsIBA 05/2014 - 11/2002
5	AntigensIBA 01/2020 - 05/2008
4	Therapeutic UsesIBA 12/2021 - 01/2018
4	TNF-Related Apoptosis-Inducing LigandIBA 12/2017 - 06/2010
3	AntibodiesIBA 01/2020 - 04/2008
3	Phosphotransferases (Kinase)IBA 01/2020 - 02/2014
3	Pharmaceutical PreparationsIBA 01/2019 - 02/2013
3	Transforming Growth Factor beta (TGF-beta)IBA 02/2010 - 07/2004
3	ProdrugsIBA 07/2009 - 06/2002
2	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 01/2019
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2014 - 05/2008
2	protein kinase DIBA 02/2014 - 11/2007
2	Estrogen Receptor Modulators (Antiestrogen)IBA 02/2010 - 07/2004
2	Indicators and Reagents (Reagents)IBA 03/2009 - 08/2003
2	Surface Antigens (Surface Antigen)IBA 05/2008 - 08/2003
2	Peptide Hydrolases (Proteases)FDA Link 12/2006 - 06/2002
2	Fas Ligand Protein (Fas Ligand)IBA 02/2005 - 02/2003
1	Interleukin-12 (IL 12)IBA 12/2021
1	Macrophage Colony-Stimulating FactorIBA 12/2021
1	Single-Domain AntibodiesIBA 01/2020
1	pembrolizumabIBA 01/2020
1	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 01/2020
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	Alanine Transaminase (SGPT)IBA 01/2020
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	EndoglinIBA 01/2019
1	Monoclonal AntibodiesIBA 01/2019
1	Streptonigrin (Nigrin)IBA 01/2019
1	Glutamic Acid (Glutamate)FDA Link 01/2019
1	Immunoconjugates (Immunoconjugate)IBA 01/2019
1	PerforinIBA 01/2019
1	Epithelial Cell Adhesion MoleculeIBA 02/2018
1	Immunoglobulin FragmentsIBA 02/2018
1	Immunoglobulin G (IgG)IBA 01/2018
1	ImmunosorbentsIBA 01/2016
1	EnzymesIBA 01/2016
1	Liposomes (Liposome)IBA 05/2014
1	Single-Chain AntibodiesIBA 05/2014
1	Matrix Metalloproteinases (MMPs)IBA 02/2014
1	Protein Kinase D2IBA 02/2014
1	Protein Isoforms (Isoforms)IBA 02/2014
1	Biological ProductsIBA 01/2014
1	Cetuximab (Erbitux)FDA Link 01/2014
1	Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA 08/2013
1	Chimeric Antigen ReceptorsIBA 08/2013
1	Proteasome InhibitorsIBA 02/2013
1	CaspasesIBA 02/2013
1	Bortezomib (Velcade)FDA Link 02/2013
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2011
1	Estrogen ReceptorsIBA 02/2010
1	Actin Depolymerizing Factors (Cofilins)IBA 07/2009
1	LipidsIBA 07/2009
1	Recombinant ProteinsIBA 01/2009

Therapy/Procedure

19	Therapeutics 01/2021 - 08/2003
3	Immunotherapy 01/2020 - 08/2013
2	Drug Therapy (Chemotherapy) 01/2020 - 11/2002
1	Injections 02/2018
1	Peritoneal Dialysis 01/2016
1	Heterologous Transplantation (Xenotransplantation) 06/2010